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Reductive Etherification via Anion-Binding Catalysis

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journal contribution
posted on 2017-07-25, 13:49 authored by Chenfei Zhao, Christopher A. Sojdak, Wazo Myint, Daniel Seidel
Reductive condensations of alcohols with aldehydes/ketones to generate ethers are catalyzed by a readily accessible thiourea organocatalyst that operates in combination with HCl. 1,1,3,3-tetramethyldisiloxane serves as a convenient reducing reagent. This strategy is applicable to challenging substrate combinations and exhibits functional group tolerance. Competing reductive homocoupling of the carbonyl component is suppressed.

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