posted on 2017-07-25, 13:49authored byChenfei Zhao, Christopher A. Sojdak, Wazo Myint, Daniel Seidel
Reductive condensations
of alcohols with aldehydes/ketones to generate ethers are catalyzed
by a readily accessible thiourea organocatalyst that operates in combination
with HCl. 1,1,3,3-tetramethyldisiloxane serves as a convenient reducing
reagent. This strategy is applicable to challenging substrate combinations
and exhibits functional group tolerance. Competing reductive homocoupling
of the carbonyl component is suppressed.