Redox
and Near-Infrared
Light-Responsive Nanoplatform
for Enhanced Pesticide Delivery and Pest Control in Rice: Construction,
Efficacy, and Potential Mechanisms
posted on 2023-08-16, 08:29authored byMao Zong, Chang Yu, Jiaqing Li, Dan Sun, Jiayin Wang, Ziyao Mo, Chuwei Qin, Disi Yang, Zhaoyang Zhang, Qinghong Zeng, Chengyue Li, Kangsheng Ma, Hu Wan, Jianhong Li, Shun He
The brown planthopper, Nilaparvata lugens (Stål), is a major rice
pest in various Asian countries,
causing significant negative impacts on rice yield and quality. In
this study, we developed a novel nanoplatform (NIT@MON@CuS) for pesticide
delivery that responds to redox and near-infrared light stimuli. The
nanoplatform consisted of CuS nanoparticles with mesoporous organic
silica (MON), loaded with nitenpyram (NIT). With an average size of
190 nm and a loading efficiency of 22%, NIT@MON@CuS exhibited remarkable
thermal response in the near-infrared region, demonstrating excellent
photothermal conversion ability and stability. In vitro release kinetics
demonstrated the rapid release of nitenpyram under near-infrared light
and glutathione conditions, facilitating a satisfactory temperature
increase and accelerated drug release. The NIT@MON@CuS-treated group
exhibited a higher mortality of N. lugens, increasing from 62 to 88% compared to the group treated with nitenpyram
technical after 96 h. Bioassay revealed that NIT@MON@CuS significantly
enhanced nitenpyram toxicity by more than 1.4-fold against both laboratory
insecticide-resistant and field strains of N. lugens. Furthermore, RT-qPCR results demonstrated that MON@CuS had the
capability to reduce P450 gene expression, thereby improving the sensitivity
of N. lugens to insecticides. These
findings suggest that MON@CuS holds great potential as an intelligent
pest control platform, offering a sustainable and efficient approach
to protect crops against pests.