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Redox-Neutral Palladium-Catalyzed C–H Functionalization To Form Isoindolinones with Carboxylic Acids or Anhydrides as Readily Available Starting Materials

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journal contribution
posted on 05.06.2015, 00:00 by Hong-Wen Liang, Wei Ding, Kun Jiang, Li Shuai, Yi Yuan, Ye Wei, Ying-Chun Chen
An operationally simple, Pd-catalyzed C–H functionalization is described for the synthesis of important and useful isoindolinones from readily available carboxamides and carboxylic acids or anhydrides. The reactions proceed efficiently with a broad range of substrates under redox-neutral reaction conditions and tolerate a diversity of functional groups. The mechanistic investigation suggests that the reactions involve C–H activation, nucleophilic addition, β-O elimination, and dehydration steps.