posted on 2016-01-19, 00:00authored byDongsheng Wang, Si Wu
Red-light-responsive
supramolecular valves constructed by tetra-ortho-methoxy-substituted
azobenzene (mAzo) and β-cyclodextrin
(β-CD) were used to control drug release from mesoporous silica
nanoparticles (MSNs). Doxorubicin (DOX) was used as a model drug and
loaded into nanopores of mAzo modified MSNs. β-CD formed supramolecular
valves with mAzo by host–guest interaction and closed the nanopores.
Red light was able to open the supramolecular valves and induce DOX
release even in deep tissue.