American Chemical Society
ol400917j_si_001.pdf (10.93 MB)

Ready Synthetic Access to Enantiopure Allylic α(F)-Branched Fluoroalkenes

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journal contribution
posted on 2016-02-19, 08:44 authored by Florent Larnaud, Julien Malassis, Emmanuel Pfund, Bruno Linclau, Thierry Lequeux
Convenient access to homochiral fluoroalkenes is described via a Julia–Kocienski olefination reaction. The required homochiral fluorosulfone is synthesized by a Mitsunobu reaction from readily available enantiopure secondary alcohols.