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Reactions of Difluorocarbene with Organozinc Reagents

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journal contribution
posted on 15.02.2013, 00:00 by Vitalij V. Levin, Artem A. Zemtsov, Marina I. Struchkova, Alexander D. Dilman
Reactions of difluorocarbene with benzyl and alkylzinc halides leading to fluorinated organozinc species have been described. The generated α-difluorinated organozinc reagents are reasonably stable in solution and can be quenched with external electrophiles (iodine, bromine, proton), affording compounds containing the CF2 fragment.