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Reaction Based Fluorescent Probes for Hydrogen Sulfide

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journal contribution
posted on 21.02.2016, 14:09 by Chunrong Liu, Bo Peng, Sheng Li, Chung-Min Park, A. Richard Whorton, Ming Xian
A reaction based fluorescence turn-on strategy for hydrogen sulfide (H2S) was developed. This strategy was based on a H2S-specific Michael addition–cyclization sequence. Other biological thiols such as cysteine and glutathione did not pursue the reaction and therefore did not turn on the fluorescence/consume the substrates. The probes showed good selectivity and sensitivity for hydrogen sulfide.