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Rational Design of a Multifunctional Molecular Dye with Single Dose and Laser for Efficiency NIR-II Fluorescence/Photoacoustic Imaging Guided Photothermal Therapy
journal contribution
posted on 2019-09-10, 15:42 authored by Ruiping Zhang, Zhenjun Wang, Liying Xu, Yuling Xu, Yi Lin, Ying Zhang, Yao Sun, Guangfu YangMultifunctional
probes integrating accurate multidiagnosis and
efficient therapy hold great prospects in biomedical research. However,
the sophisticated construction and difficulties in matching the ratios
of doses and laser triggers of probes for each modal imaging and therapy
still hinder the extensive practice of multifunctional probes in biomedicine.
We herein rationally designed an organic dye SY1080 with intrinsic
multifunction by introducing both 3,4-ethylenedioxy thiophene (EDOT)
and the selenium containing acceptor unit into the backbone to balance
the fluorescent brightness and emission wavelength. Under single dose
and 808 nm laser irradiation conditions, SY1080 not only carried out
NIR-II fluorescence/photoacoustic imaging of real-time and noninvasive
tumor delineation with excellent contrast, but also effectively ablated
tumors with laser irradiation to perform photothermal therapy under
the guidance of dual-modal imaging. These exciting results highlight
SY1080 as a multifunctional and universal phototheranostic platform
for potential applications.