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Rational Construction of a Two-Photon NIR Ratiometric Fluorescent Probe for the Detection of Bisulfite in Live Cells, Tissues, and Foods

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posted on 07.06.2022, 09:03 authored by Jingcan Qin, Fei Kong, Yuanyuan Guo, Dongya Wang, Chuan Zhang, Yuehua Li
In this study, we report a novel ratiometric fluorescent probe with a blue shift of 180 nm based on a D-π-A-A structure. The probe composed of a hydroxyl moiety as a donor, a naphthyl ring as a π bridge, and benzothiazole/hemicyanine as an acceptor has good selectivity and high sensitivity to bisulfite (HSO3) in aqueous solution. Besides one-photon fluorescence properties, the probe possesses excellent two-photon fluorescence properties and is successfully utilized for fluorescence imaging of HSO3 in MCF-7 cells and rat liver tissues. More importantly, the probe also has practical application potential for measuring the HSO3 content of real food samples.