Rare Earth Amide-Catalyzed
Direct Thioesterification
of Aldehydes with Thiols under Mild Conditions

Ismaeel, Nadia; Imran, Sajid; Zhu, Xuehua; Chen, Jue; Yuan, Dan; Yao, Yingming

doi:10.1021/acs.orglett.3c03497.s001

ol3c03497_si_001.pdf (2.42 MB)

Rare Earth Amide-Catalyzed Direct Thioesterification of Aldehydes with Thiols under Mild Conditions

journal contribution

posted on 2023-11-24, 00:19 authored by Nadia Ismaeel, Sajid Imran, Xuehua Zhu, Jue Chen, Dan Yuan, Yingming Yao

Direct thioesterification of aldehydes with thiols catalyzed by readily accessible rare earth/lithium amide RE[N(SiMe₃)₂]₃(μ-Cl)Li(THF)₃ is developed, which enables the preparation of a range of thioesters (31 examples) under room temperature and solvent-free conditions, without using any additive or external oxidant. This method provides a straightforward and atom-efficient approach for the thioester synthesis.