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Rare A‑Type, Spiro-Type, and Highly Oligomeric Proanthocyanidins from Pinus massoniana

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journal contribution
posted on 08.07.2020, 16:09 by Bin Zhou, Yvette Alania, Mariana C. Reis, James B. McAlpine, Ana K. Bedran-Russo, Guido F. Pauli, Shao-Nong Chen
An investigation of the dental bioactive proanthocyanidin (PAC) oligomer fractions led to three structurally distinct new PACs (13) from pine bark. Pinutwindoublin (1) is the first reported trimer with double A-type interflavanyl linkages (2α→O→5,4α→6 and 2α→O→7,4α→8). Pinuspirotetrin (2) represents the first reported PAC tetramer with a heterodimeric framework consisting of one spiro-type and one A-type dimer. Pinumassohexin (3) was elucidated as a mixed A + B-type hexamer that consists of a peanut-derived tetramer, peanut procyanidin E, and an A-type dimer (5). Compound 3 increased the modulus of elasticity of dentin by an impressive 4.3 times at a concentration of 0.65%.

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