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Rapid and Scalable Access into Strained Scaffolds through Continuous Flow Photochemistry

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journal contribution
posted on 28.12.2015, 00:00 by Daniel Blanco-Ania, Sagar Ashok Gawade, Luc J. L. Zwinkels, Luuk Maartense, Marjon G. Bolster, Jorg C. J. Benningshof, Floris P. J. T. Rutjes
Two conformationally restricted three-dimensional aminoketone scaffolds have been synthesized in only three steps, using a continuous flow photochemistry approach, which is also amenable to scale-up. In addition, several approaches to further derivatize these scaffolds for the synthesis of low molecular weight compound libraries have been detailed.