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Rapid and Controllable Design of Robust Superwettable Microchips by a Click Reaction for Efficient o‑Phthalaldehyde and Glucose Detection

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journal contribution
posted on 08.10.2019, 22:03 by Jianying Huang, Hui Yang, Jiajun Mao, Fang Guo, Yan Cheng, Zhong Chen, Xiaoqin Wang, Xiao Li, Yuekun Lai
Superwettable patterns with superhydrophobic and superhydrophilic units have the capacity of enriching and absorbing microdroplets for multifunctional biosensing. Combining the advantages of superwettable micropatterns and a rapid click reaction, we first prepared a film using propargyl methacrylate–ethylene dimethacrylate and then created a superhydrophobic–superhydrophilic micropattern by a rapid thiol–yne click reaction. Due to the high wettability contrast, water droplets tend to be anchored in the superhydrophilic region. Molecules dissolved in a water droplet are therefore uniformly enriched in the superhydrophilic region after evaporation because of the Malangoni effect. This provides a rational strategy to develop novel patterned microchips for sensing applications. Combining with fluorescence imaging technology, the Ti superwettable microchip can be used to detect o-phthalaldehyde in water, with a detection limit as low as 10–7 mol L–1. In addition, taking advantage of the oxidative color rendering ability of glucose, the microchip, when fabricated on a glass substrate, can realize reuseable glucose detection with a detection limit of 2 mM within 15 min.