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Rapid Two-Step Synthesis of Mitrin from Heparosan:  A Replacement for Heparin

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journal contribution
posted on 23.09.2003, 00:00 by Balagurunathan Kuberan, David L. Beeler, Roger Lawrence, Miroslaw Lech, Robert D. Rosenberg
We have engineered a two-step enzymatic synthesis of Mitrin which is a more potent and homogeneous anticoagulant than the current animal-derived heparin. This engineered heparin may have advantages of being free from animal-derived pathogens and may also have reduced side effects such as heparin induced thrombocytopenia. This approach can also be extended to tailor heparin-based drugs with improved therapeutic characteristics to treat other disorders or infections in which heparin-like molecules play a major role.