jm051118z_si_001.pdf (1.47 MB)
Rapid Synthesis of Triazole-Modified Resveratrol Analogues via Click Chemistry
journal contribution
posted on 2006-01-26, 00:00 authored by Francesca Pagliai, Tracey Pirali, Erika Del Grosso, Riccardo Di Brisco, Gian Cesare Tron, Giovanni Sorba, Armando A. GenazzaniResveratrol is a phytoalexin able to display an array of
biological activities. We decided to replace the double bond with a
triazole ring using the archetypical click reaction: the Huisgen [3 +
2] cycloaddition. Seventy-two triazole derivatives were synthesized via
a parallel combinatorial approach. Preliminary data suggest that this
procedure can lead to the synthesis of compounds that display some,
but not all, of resveratrol's actions with increased potency.