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Rapid Enantiomeric Excess and Concentration Determination Using Simple Racemic Metal Complexes

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journal contribution
posted on 20.11.2008, 00:00 by Sonia Nieto, Vincent M. Lynch, Eric V. Anslyn, Hyunwoo Kim, Jik Chin
Racemic-metal complexes were used to determine identity, enantiomeric excess, and concentration of chiral diamines using metal-to-ligand charge transfer bands in circular dichroism spectroscopy. It takes under just 2 min per sample to determine [G]t and %R with tolerable errors (19% and 4%, respectively). The simplicity of the achiral receptors employed confers to this technique great potential for high-throughput screening.

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