ol802085j_si_002.pdf (499.66 kB)

Rapid Enantiomeric Excess and Concentration Determination Using Simple Racemic Metal Complexes

Download (499.66 kB)
journal contribution
posted on 20.11.2008, 00:00 by Sonia Nieto, Vincent M. Lynch, Eric V. Anslyn, Hyunwoo Kim, Jik Chin
Racemic-metal complexes were used to determine identity, enantiomeric excess, and concentration of chiral diamines using metal-to-ligand charge transfer bands in circular dichroism spectroscopy. It takes under just 2 min per sample to determine [G]t and %R with tolerable errors (19% and 4%, respectively). The simplicity of the achiral receptors employed confers to this technique great potential for high-throughput screening.