American Chemical Society
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Rapid, Easy Cyanation of Aryl Bromides and Chlorides Using Nickel Salts in Conjunction with Microwave Promotion

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journal contribution
posted on 2003-10-14, 00:00 authored by Riina K. Arvela, Nicholas E. Leadbeater
We report here a fast, easy, and efficient method for the preparation of aryl nitriles from aryl bromides and chlorides. The methodology for aryl bromides involves the use of either Ni(CN)2 or NaCN and NiBr2. With aryl chlorides, a mix of NaCN and NiBr2 is used and the reaction proceeds via the in situ formation of the corresponding aryl bromide. The reaction can be performed in air and is complete within 10 min.