ol9b00285_si_001.pdf (2.33 MB)

Rapid Construction of the Common [5–5–6] Tricyclic Ring Skeleton in Polycyclic Cembranoids and Norcembranoids via Intramolecular 1,3-Dipolar Cycloaddition

Download (2.33 MB)
journal contribution
posted on 21.02.2019, 15:06 by Meng Deng, Xiao Zhang, Zining Li, Hongbin Chen, Shaoli Zang, Guangxin Liang
A synthetically challenging bowl-shaped [5–5–6] tricyclic framework commonly seen in many polycyclic cembranoids and norcembranoids was strategically established in a convenient six-step sequence featuring an intramolecular 1, 3-dipolar cycloaddition reaction. Synthetic manipulations of such a valuable intermediate were explored for future applications.