Rapid Amination of Methoxy Pyridines with Aliphatic Amines
journal contribution
posted on 2019-07-22, 14:12 authored by Xia Wang, Cheng-Yu Long, Min-Hui Su, Yi-Xin Qu, Shen-Huan Li, Xiao-Jing Zhang, Si-Jie Huang, Xue-Qiang WangA n-BuLi triggered practical amination protocol
of methoxy pyridine derivatives with aliphatic amines was developed.
The reaction could finish in 30 min for primary amines and 10 min
for secondary amines. The amination is further highlighted by its
excellent reactivity and substrate scope.
