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Rapid Access to Hindered α‑Amino Acid Derivatives and Benzodiazepin-3-ones from Aza-Oxyallyl Cations

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journal contribution
posted on 2020-01-17, 18:33 authored by YongIl Kwon, Sunyoung Choi, Hyun Sun Jang, Sung-Gon Kim
Catalyst-free and mild synthetic methods for the construction of hindered α-amino acid derivatives are presented herein. A wide range of hindered amino acid amides can be readily obtained from the reaction of α-halohydroxamates with a variety of amines, including anilines, primary amines, and secondary amines. Moreover, the aza/aza-[4+3] cycloaddition of in situ-generated aza-oxyallyl cations with 2-aminophenyl α,β-unsaturated carbonyls to furnish seven-membered benzodiazepin-3-ones is reported for the first time.