posted on 2018-06-07, 16:37authored byHarekrishna Sahoo, Saibal Singh, Mahiuddin Baidya
A radical-based cascade
reaction has been devised for oxidative
difunctionalization of aryl alkynoates at room temperature to access
stereodefined fully substituted α,β-unsaturated acids
bearing a chalcogen functionality in high yields (up to 95%). The
protocol is operationally simple, metal-free, scalable, and suppresses
the usual CO2 exclusion phenomenon. The utility of this
method was showcased in the synthesis of vinyl halides, vinyl selenides,
and 3,3-disubstituted indanones.