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Radical Arylalkoxycarbonylation of 2‑Isocyanobiphenyl with Carbazates: Dual C–C Bond Formation toward Phenanthridine-6-carboxylates

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journal contribution
posted on 06.06.2014, 00:00 by Changduo Pan, Jie Han, Honglin Zhang, Chengjian Zhu
A sequential oxidative radical alkoxycarbonylation and aromatization of 2-isocyanobiphenyl with carbazates was developed to furnish phenanthridine-6-carboxylates. Various functional groups such as methoxy, chloro, fluoro, trifluoromethoxy, and trifluoromethyl groups were tolerated well under the reaction conditions. The sequential radical addition–cyclization strategy represents a practical route to access phenanthridine-6-carboxylates.