jo2c00037_si_001.pdf (9.81 MB)
Radical Acylalkylation of 1,3-Enynes To Access Allenic Ketones via N‑Heterocyclic Carbene Organocatalysis
journal contributionposted on 2022-03-29, 17:15 authored by Yan-Qing Liu, Qing-Zhu Li, Xin-Xin Kou, Rong Zeng, Ting Qi, Xiang Zhang, Cheng Peng, Bo Han, Jun-Long Li
An N-heterocyclic carbene organocatalytic 1,4-difunctionalization of 1,3-enynes was developed. This organocatalytic strategy was suitable for a broad spectrum of substrates to efficiently synthesize allenic ketones bearing diverse substituents. Preliminary mechanistic studies suggest a radical reaction pathway for this organocatalytic acylalkylation process.