posted on 2020-07-23, 17:49authored byHuihui Zhang, Luyao Kou, Dong Chen, Meishan Ji, Xiaoguang Bao, Xinxin Wu, Chen Zhu
Herein we describe an efficient distal
ipso-migration of O- and S-containing
heteroaryls and the
radical heteroarylation of unactivated alkenes. The migration is triggered
by various fluoroalkyl radicals, leading to valuable multifunctionalized
ketones. The comparisons of migratory aptitude for O-/S-containing heteroaryls are comprehensively investigated.
The origin of the chemoselective migration could be partially attributed
to the discrepancy in the energy level of the LUMO of each heteroaryl
group.