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Quorumolides A–C, Three Cembranoids from Euphorbia antiquorum

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journal contribution
posted on 25.12.2017, 00:00 by Wei-Yan Qi, Jin-Xin Zhao, Wen-Jun Wei, Kun Gao, Jian-Min Yue
Three highly modified cembranoids, quorumolides A–C (13), were isolated from Euphorbia antiquorum. Compound 1 is the first example of a cembranoid embedding an α,β-unsaturated-γ-lactone and a tetrahydro-2H-pyran motif within the 14-membered ring. Biosynthetically, it is particularly noteworthy that the stereochemistries of C-2 and C-12 in the pyran ring of 13 were opposite to those of marine-derived rare cembranoids.