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Quaternary Carbon Center Forming Formal [3 + 3] Cycloaddition Reaction via Bifunctional Catalysis: Asymmetric Synthesis of Spirocyclohexene Pyrazolones
journal contribution
posted on 2017-03-24, 19:06 authored by Jin-Yu Liu, Jing Zhao, Jia-Lu Zhang, Peng-Fei XuA variety of spirocyclohexene pyrazolones
were synthesized in good
yields with excellent stereoselectivities through an asymmetric, intermolecular,
quaternary carbon center forming [3 + 3] cycloaddition reaction catalyzed
by a bifunctional catalyst. The vinylogous pyrazolones used as binucleophilic
synthons in this reaction exhibited superior ability for constructing
pyrazolone related spirocyclic scaffolds.