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Pyrrolo[3,4‑c]pyridine-Based Fluorescent Chemosensor for Fe3+/Fe2+ Sensitivity and Their Application in Living HepG2 Cells

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posted on 2018-12-28, 10:33 authored by Pampa Maity, Barnali Naskar, Sanchita Goswami, Chandraday Prodhan, Tandrima Chaudhuri, Keya Chaudhuri, Chhanda Mukhopadhyay
New 2H-pyrrolo­[3,4-c]­pyridine-1,3,6­(5H)-trione-based fluorophores have been synthesized by a single-step procedure in an ambient reaction condition. By this protocol, a total of 44 new compounds were generated and the photophysical property of 23 compounds was studied in detail. These fluorophores show good fluorescence activity and illustrate high selectivity for Fe3+/Fe2+ cation in the 10–7 (M) range. Notably, this 2H-pyrrolo­[3,4-c]­pyridine-1,3,6­(5H)-trione moiety is first used as a turn-off chemosensor for the Fe3+/Fe2+ cation. In addition, this probe was further applied for imaging Fe3+ in living HepG2 cells.

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