Pyrrolo[3,4‑c]pyridine-Based Fluorescent Chemosensor for Fe3+/Fe2+ Sensitivity and Their Application in Living HepG2 Cells
journal contribution
posted on 2018-12-28, 10:33 authored by Pampa Maity, Barnali Naskar, Sanchita Goswami, Chandraday Prodhan, Tandrima Chaudhuri, Keya Chaudhuri, Chhanda MukhopadhyayNew
2H-pyrrolo[3,4-c]pyridine-1,3,6(5H)-trione-based fluorophores have been synthesized by a
single-step procedure in an ambient reaction condition. By this protocol,
a total of 44 new compounds were generated and the photophysical property
of 23 compounds was studied in detail. These fluorophores show good
fluorescence activity and illustrate high selectivity for Fe3+/Fe2+ cation in the 10–7 (M) range.
Notably, this 2H-pyrrolo[3,4-c]pyridine-1,3,6(5H)-trione moiety is first used as a turn-off chemosensor
for the Fe3+/Fe2+ cation. In addition, this
probe was further applied for imaging Fe3+ in living HepG2
cells.
