Pyranoflavanones and Pyranochalcones from the Fruits
of Amomum tsao-ko

Kim, Jun Gu; Jang, Hari; Le, Thi Phuong Linh; Hong, Hye Ryoung; Lee, Mi Kyeong; Hong, Jin Tae; Lee, Dongho; Hwang, Bang Yeon

doi:10.1021/acs.jnatprod.9b00155.s001

Pyranoflavanones and Pyranochalcones from the Fruits of Amomum tsao-ko

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posted on 2019-06-25, 14:39 authored by Jun Gu Kim, Hari Jang, Thi Phuong Linh Le, Hye Ryoung Hong, Mi Kyeong Lee, Jin Tae Hong, Dongho Lee, Bang Yeon Hwang

Eight new geranylated and farnesylated pyranoflavanones (1–8) and two new farnesylated pyranochalcones (9 and 10) were isolated from the methanolic extract of the fruits of Amomum tsao-ko. Their structures were elucidated by extensive analysis of the 1D and 2D NMR spectra and from the HRESIMS, combined with experimental ECD data. All compounds were evaluated for their inhibitory effects on the nitric oxide production against lipopolysaccharide-induced RAW 264.7 macrophages and exhibited IC₅₀ values ranging from 10.6 to 41.5 μM.

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geranylated data ECD 41.5 μ M 10.6 pyranoflavanone Pyranochalcone 2 D NMR spectra IC 50 values Pyranoflavanone nitric oxide production pyranochalcone compound farnesylated Amomum tsao-ko lipopolysaccharide-induced RAW 264.7 macrophages analysis HRESIMS methanolic

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Pyranoflavanones and Pyranochalcones from the Fruits of Amomum tsao-ko

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