np9b00155_si_001.pdf (3.25 MB)
Pyranoflavanones and Pyranochalcones from the Fruits of Amomum tsao-ko
journal contribution
posted on 2019-06-25, 14:39 authored by Jun Gu Kim, Hari Jang, Thi Phuong Linh Le, Hye Ryoung Hong, Mi Kyeong Lee, Jin Tae Hong, Dongho Lee, Bang Yeon HwangEight new geranylated and farnesylated
pyranoflavanones (1–8) and two new
farnesylated pyranochalcones
(9 and 10) were isolated from the methanolic
extract of the fruits of Amomum tsao-ko. Their structures
were elucidated by extensive analysis of the 1D and 2D NMR spectra
and from the HRESIMS, combined with experimental ECD data. All compounds
were evaluated for their inhibitory effects on the nitric oxide production
against lipopolysaccharide-induced RAW 264.7 macrophages and exhibited
IC50 values ranging from 10.6 to 41.5 μM.