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Pure Water-Induced Dehalogenation of 2,4-Di-tert-amino-6-substituted-5-halogenopyrimidines

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journal contribution
posted on 20.03.2018, 00:00 by Mahsa Mousavi, Mehdi Bakavoli, Ali Shiri, Hossein Eshghi
Dehalogenation of 5-halogenopyrimidine derivatives in boiling pure water was accomplished in high yields. The substrate and pure water are the only two reaction components in this process. Dehalogenation takes place in the absence of any catalysts, additives, basic, or acidic conditions, introducing water as a potential dehalogenation reagent.