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Psiguadials A and B, Two Novel Meroterpenoids with Unusual Skeletons from the Leaves of Psidium guajava

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journal contribution
posted on 05.11.2010, 00:00 by Meng Shao, Ying Wang, Zhong Liu, Dong-Mei Zhang, Hui-Hui Cao, Ren-Wang Jiang, Chun-Lin Fan, Xiao-Qi Zhang, He-Ru Chen, Xin-Sheng Yao, Wen-Cai Ye
Psiguadials A (1) and B (2), two novel sesquiterpenoid-diphenylmethane meroterpenoids with unusual skeletons, along with a pair of known epimers, psidial A (3) and guajadial (4), were isolated from the leaves of Psidium guajava. Their structures with absolute configurations were elucidated by means of NMR, X-ray diffraction, and quantum chemical CD calculation. Compounds 1, 2, and 4 exhibited potent inhibitory effects on the growth of human hepatoma cells.