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Protein Patterning Based on Electrochemical Activation of Bioinactive Surfaces with Hydroquinone-Caged Biotin

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journal contribution
posted on 01.12.2004, 00:00 authored by Kyuwon Kim, Haesik Yang, Sangyong Jon, Eunkyung Kim, Juhyoun Kwak
We report a protein attachment and patterning method based on a hydroquinone-caged biotin surface that generates bioactive biotin by mild electrochemical perturbation. The electrochemical activation proceeds under the buffered aqueous environment at neutral pH. It also allows site-selective generation of bioactive biotin for the immobilization of target protein by using prepatterned electrode arrays.