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Download fileProcess Intensification with Bifunctional Heterogeneous Catalysts: Selective One-Pot Synthesis of 2′-Aminochalcones
journal contribution
posted on 2015-01-02, 00:00 authored by M. J. Climent, A. Corma, S. Iborra, L. Martí2′-Aminochalcones
of pharmaceutical and commercial interest
have been obtained in high yields and selectivities through a one-pot
process using a bifunctional heterogeneous catalyst bearing base and
metal active sites. This is a physical mixture material formed by
a high-surface-area MgO and Pt on TiO2. The process involves
as the first step the Claisen–Schmidt condensation between o-nitroacetophenone and benzaldehyde derivatives on the
basic catalytic function. This is followed by a chemoselective hydrogenation
of the nitro group in the presence of the carbonyl and double-bond
carbon–carbon groups within the molecule. Using the bifunctional
catalyst and the reaction system proposed here, it is possible to
produce, under mild reaction conditions and short reaction times,
2′-aminochalcones with higher yields and selectivities than
those obtained by conventional multistep methods.