Process Development of
Citalopram/Escitalopram Oxalate:
Isolation and Synthesis of Novel Impurities

Pramanik, Chinmoy; Hivarekar, Raghvendra R.; Deshmukh, Sanjay S.; Tripathy, Narendra
K.; Kotharkar, Sandeep; Chaudhari, Ashok; Gurjar, Mukund K.

doi:10.1021/op300039c.s001

Process Development of Citalopram/Escitalopram Oxalate: Isolation and Synthesis of Novel Impurities

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posted on 2012-05-18, 00:00 authored by Chinmoy Pramanik, Raghvendra R. Hivarekar, Sanjay S. Deshmukh, Narendra K. Tripathy, Sandeep Kotharkar, Ashok Chaudhari, Mukund K. Gurjar

During process optimization of Escitalopram oxalate novel impurities, 6 and 7 were observed, which were isolated and characterized, and the proposed structure was confirmed by chemical synthesis. Investigation of the cause of impurities formation improved the yield and purity of the drug product during the bulk API synthesis.

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Oxalate chemical synthesis Escitalopram oxalate novel impurities drug product impurity Citalopram investigation impurities formation Synthesi bulk API synthesis Novel ImpuritiesDuring process optimization purity Isolation process Development

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Process Development of Citalopram/Escitalopram Oxalate: Isolation and Synthesis of Novel Impurities

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