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Probing the Lactose·GM3 Carbohydrate−Carbohydrate Interaction with Glycodendrimers

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journal contribution
posted on 05.02.2009, 00:00 by Nicole Seah, Paul V. Santacroce, Amit Basu
Multivalent glycoconjugates were prepared using generation-4 PAMAM dendrimers, and their interaction with Langmuir monolayers containing GM3 was investigated. Excessive carbohydrate valency adversely affects the carbohydrate−carbohydrate interaction. The GM3 monolayer selectively interacts with lactose-functionalized dendrimers in the presence of calcium ions.