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Pro-Antimicrobial Networks via Degradable Acetals (PANDAs) Using Thiol–Ene Photopolymerization

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journal contribution
posted on 2017-02-06, 13:03 authored by Dahlia N. Amato, Douglas V. Amato, Olga V. Mavrodi, William B. Martin, Sarah N. Swilley, Keith H. Parsons, Dmitri V. Mavrodi, Derek L. Patton
We describe the synthesis of pro-antimicrobial networks via degradable acetals (PANDAs) as a new paradigm for sequestration and triggered release of volatile, bioactive aldehydes. PANDAs derived from diallyl p-chlorobenzaldehyde acetal degrade and release p-chlorobenzaldehyde as an antibacterial and antifungal agent under mild conditions (pH 7.4/high humidity). We show that PANDAs enable facile access to materials with tunable release profiles, potent antimicrobial activity without triggering antimicrobial resistance, and minimal cytotoxicity.

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