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Printable Nonenzymatic Glucose Biosensors Using Carbon Nanotube-PtNP Nanocomposites Modified with AuRu for Improved Selectivity
journal contribution
posted on 2020-08-12, 21:46 authored by Tran N.
H. Nguyen, Xin Jin, James K. Nolan, Jian Xu, Khanh Vy H. Le, Stephanie Lam, Yi Wang, Muhammad A. Alam, Hyowon LeeNonenzymatic
glucose biosensors have the potential for a more reliable
in vivo functionality due to the reduced risk of biorecognition element
degradation. However, these novel sensing mechanisms often are nanoparticle-based
and have nonlinear responses, which makes it difficult to gauge their
potential utility against more conventional enzymatic biosensors.
Moreover, these nonenzymatic biosensors often suffer from poor selectivity
that needs to be better addressed before being used in vivo. To address
these problems, here we present an amperometric nonenzymatic glucose
biosensor fabricated using one-step electrodeposition of Au and Ru
nanoparticles on the surface of a carbon-nanotube-based platinum–nanoparticle
hybrid in conductive polymer. Using benchtop evaluations, we demonstrate
that the bimetallic catalyst of Au-Ru nanoparticles can enable the
nonenzymatic detection of glucose with a superior performance and
stability. Furthermore, our biosensor shows good selectivity against
other interferents, with a nonlinear dynamic range of 1–19
mM glucose. The Au-Ru catalyst has a conventional linear range of
1–10 mM, with a sensitivity of 0.2347 nA/(μM mm2) ± 0.0198 (n = 3) and a limit of detection
of 0.068 mM (signal-to-noise, S/N = 3). The biosensor also exhibits a good repeatability and stability
at 37 °C over a 3 week incubation period. Finally, we use a modified
Butler–Volmer nonlinear analytical model to evaluate the impact
of geometrical and chemical design parameters on our nonenzymatic
biosensor’s performance, which may be used to help optimize
the performance of this class of biosensors.
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Keywords
nonlinear responsesnonenzymatic biosensorsAu-Ru nanoparticleschemical design parametersCarbon Nanotube-PtNP Nanocomposites...Selectivity Nonenzymatic glucose bi...3 week incubation periodvivo functionalityAu-Ru catalyst0.068 mMbenchtop evaluationsamperometric nonenzymatic glucose b...nonenzymatic detectionconductive polymerbimetallic catalystbiorecognition element degradationperformancePrintable Nonenzymatic Glucose Bios...Ru nanoparticles
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