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Preparation of α-Alkyl-β-Amino Acids via β-Alanine Ni(II) Complex

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journal contribution
posted on 2011-08-19, 00:00 authored by Daizong Lin, Li Lv, Jiang Wang, Xiao Ding, Hualiang Jiang, Hong Liu
A new β-amino acrylic acid Ni(II) complex has been developed and used for the synthesis of α-alkyl-β-amino acids via alkylation with alkyl halides under operationally convenient conditions. The pivotal α-alkylated intermediate can be converted into the corresponding α-alkyl-β-amino acids via two steps with a wide range of substituents.

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