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Preparation and Evaluation of Unimolecular Pentavalent and Hexavalent Antigenic Constructs Targeting Prostate and Breast Cancer:  A Synthetic Route to Anticancer Vaccine Candidates

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journal contribution
posted on 01.03.2006, 00:00 by Govind Ragupathi, Fusataka Koide, Philip O. Livingston, Young Shin Cho, Atsushi Endo, Qian Wan, Maria K. Spassova, Stacy J. Keding, Jennifer Allen, Ouathek Ouerfelli, Rebecca M. Wilson, Samuel J. Danishefsky
Several novel, fully synthetic, carbohydrate-based antitumor vaccines have been assembled. Each construct consists of multiple cancer-related antigens displayed on a single polypeptide backbone. Recent advances in synthetic methodology have allowed for the incorporation of a complex oligosaccharide terminating in a sialic acid residue (i.e., GM2) as one of the carbohydrate antigens. Details of the vaccine synthesis as well as the results of preliminary immunological investigations are described herein.