posted on 2021-08-18, 12:43authored byLing Li, Shiqi Zhang, Xiongfei Deng, Guangxun Li, Zhuo Tang, Gang Zhao
α-Imino
ketone is a useful building block for the preparation
of α-amino ketones and α-amino alcohols. However, its
preparation has been seldomly seen. Herein, a metal-free and operationally
simple strategy has been developed to generate α-imino ketones
with high regioselectivity. Meanwhile, the method allowed for the
preparation of various N,O-ketals with high regioselectivities and
diastereoselectivities through cascade reactions in one pot.