American Chemical Society
ol1c02390_si_001.pdf (8.87 MB)

Preparation and Application of α‑Imino Ketones through One-Pot Tandem Reactions Based on Heyns Rearrangement

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journal contribution
posted on 2021-08-18, 12:43 authored by Ling Li, Shiqi Zhang, Xiongfei Deng, Guangxun Li, Zhuo Tang, Gang Zhao
α-Imino ketone is a useful building block for the preparation of α-amino ketones and α-amino alcohols. However, its preparation has been seldomly seen. Herein, a metal-free and operationally simple strategy has been developed to generate α-imino ketones with high regioselectivity. Meanwhile, the method allowed for the preparation of various N,O-ketals with high regioselectivities and diastereoselectivities through cascade reactions in one pot.