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Practical Radical Cyclizations with Arylboronic Acids and Trifluoroborates

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journal contribution
posted on 21.10.2011, 00:00 by Jonathan W. Lockner, Darryl D. Dixon, Rune Risgaard, Phil S. Baran
Practical radical cyclizations using organoboronic acids and trifluoroborates take place in water, open to air, and in a scalable fashion employing catalytic silver nitrate and stoichiometric potassium persulfate. Both Pschorr-type cyclizations and tandem radical cyclization/trap cascades are described, illustrating the utility of these mild conditions for the generation of polycyclic scaffolds.