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Practical β-Lactone Synthesis:  Epoxide Carbonylation at 1 atm

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journal contribution
posted on 17.08.2006, 00:00 by John W. Kramer, Emil B. Lobkovsky, Geoffrey W. Coates
A readily prepared bimetallic catalyst is capable of effecting epoxide carbonylation to produce β-lactones at substantially lower CO pressures than previously reported catalyst systems. A functionally diverse array of β-lactones is produced in excellent yields at CO pressures as low as 1 atm. This procedure allows for epoxide carbonylation on a multigram scale without the requirement of specialized, high-pressure equipment.

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