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Download filePotential Value of Plasma Amyloid-β, Total Tau, and Neurofilament Light for Identification of Early Alzheimer’s Disease
journal contribution
posted on 2019-05-30, 00:00 authored by Yachen Shi, Xiang Lu, Linhai Zhang, Hao Shu, Lihua Gu, Zan Wang, Lijuan Gao, Jianli Zhu, Haisan Zhang, Deyu Zhou, Zhijun ZhangThe
objective of the study was to explore the potential value of
plasma indicators for identifying amnesic mild cognitive impairment
(aMCI) and determine whether levels of plasma indicators are related
to the performance of cognitive function and brain tissue volumes.
In total, 155 participants (68 aMCI patients and 87 health controls)
were recruited in the present cross-sectional study. The levels of
plasma amyloid-β (Aβ) 40, Aβ42, total tau (t-tau),
and neurofilament light (NFL) were measured using an ultrasensitive
quantitative method. Machine learning algorithms were performed for
establishing an optimal model of identifying aMCI. Compared with healthy
controls, Aβ40 and Aβ42 levels were lower and NFL levels
were higher in plasma of aMCI patients with an exception of t-tau
levels. In aMCI patients, the higher plasma Aβ40 levels were
correlated with the impaired episodic memory and negative correlations
were observed between plasma t-tau levels and global cognitive function
and gray matter (GM) volume. In addition, the higher plasma NFL levels
were correlated with reduced hippocampus volume and total GM volume
of the left inferior and middle temporal gyrus. An integrated model
included clinical features, hippocampus volume, and plasma Aβ42
and NFL and had the highest accuracy for detecting aMCI patients (accuracy,
74.2%). We demonstrated that plasma Aβ40, Aβ42, t-tau,
and NFL may be useful to identify aMCI and correlate with cognitive
decline and brain atrophy. Among these plasma indicators, Aβ42
and NFL are more valuable as key members of a peripheral biomarker
panel to detect aMCI.