posted on 2024-01-16, 21:45authored byLi Kaisu, Yang Songlin, Shuangyan Wu, Zhang Ying, Lei Wang, Andrei Potapov, Xiaolin Yu, Yaguang Sun, Na Sun, MingChang Zhu
Adenosine
triphosphate (ATP) is a small molecule that is released
to the urine from bladder urothelial cells and the bladder mucosal
band of the human body. In certain cases, ATP can serve as a biomarker
in bladder disease. For the practical applicability of luminescent
sensors for ATP in urine, it is significant to find a new strategy
for making the detection progress simple and available for in-field
urine analysis. Here, a novel luminescent lanthanide coordination
polymer (Tb-BPA) was designed and synthesized for quick and sensitive
detection of ATP through luminescence quenching with a quenching constant
of 4.90 × 103 M–1 and a detection
limit of 0.55 × 10–6 M. Besides, Tb-BPA has
excellent anti-interference ability and can detect ATP in simulated
urine with a small relative standard deviation (<4%). Moreover,
the luminescent polyacrylonitrile nanofiber films modified by Tb-BPA
were prepared by electrospinning and were used for ATP visual detection.
Notably, this film is easy to recover and reuse, and maintains good
detection performance after at least 7 cycles.