posted on 2017-12-18, 00:00authored byQian Yang, Jinrong Peng, Yao Xiao, Wenting Li, Liwei Tan, Xiaohong Xu, Zhiyong Qian
Nanoparticle-based
systems explore not only the delivery efficacy of drugs or contrast
agents, but also additional capabilities like reducing the systemic
toxicity, especially during cancer chemotherapy. Since some of the
noble metal nanoparticles exhibit the catalysis properties which can
scavenge the reactive oxygen species (ROS), they can be used as a
promising drug delivery platform for reducing the oxidative stress
damage in normal tissues caused by some chemotherapy drugs. Herein,
in this study, we construct porous Au@Pt nanoparticles and further
explore the properties of porous Au@Pt nanoparticles in relieving
the oxidative stress damage as well as in tumor growth inhibition
by chemo-photothermal co-therapy. The tunable surface pore structure
of Au@Pt nanoparticle provides space for Doxorubicin (DOX) loading.
cRGD peptide modification enable the DOX-loaded Au@Pt nanoparticles
to improve drug delivery properties. The constructed nanocarrier (DOX/Au@Pt-cRGD)
shows controlled drug release behavior. Meanwhile, the absorbance
peak of the Au@Pt structure in the near-infrared (NIR) portion provides
the capacity for in vivo photoacoustic imaging and
the high photoconversion efficiency, which make Au@Pt nanoparticle
a suitable carrier for photothermal therapy (PTT). Combined with chemotherapy,
the nanosystem DOX/Au@Pt-cRGD shows enhanced anticancer therapeutic
effects. More importantly, ROS-scavenging activity of Au@Pt alleviates
the DOX-induced oxidative stress damage, especially the cardiomyopathy
during chemotherapy. Herein, this nanosystem DOX/Au@Pt-cRGD could
be explored as reactive oxygen scavenger and drug delivery system
for side effects relieving chemo-photothermal combinational therapy.