American Chemical Society
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Polyelectrolyte-Coated Unilamellar Nanometer-Sized Magnetic Liposomes

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journal contribution
posted on 2009-06-16, 00:00 authored by Joana Filipa Pereira da Silva Gomes, Anja Rank, Astrid Kronenberger, Jürgen Fritz, Mathias Winterhalter, Yannic Ramaye
Superparamagnetic nanoparticles were encapsulated in liposomes prior to the stepwise adsorption of polyelectrolytes of opposite charges commonly known as the layer-by-layer (LbL) technique. Magnetic fields allow a fast separation of coated liposomes from unbound polyelectrolytes. The coated particles were characterized by dynamic light scattering (DLS), cryo-TEM, AFM, and zeta-potential techniques. The presence of magnetic nanoparticles and the polyelectrolyte shell opens the possibility of their magnetic manipulation and targeting by applying an external magnetic or electric field.