posted on 2023-11-17, 20:04authored byViktor Eriksson, Leyla Beckerman, Erik Aerts, Markus Andersson Trojer, Lars Evenäs
Stimulus-responsive
microcapsules pose an opportunity to achieve
controlled release of the entire load instantaneously upon exposure
to an external stimulus. Core–shell microcapsules based on
the polyanhydride poly(bis(2-carboxyphenyl)adipate) as a shell were
formulated in this work to encapsulate the model active substance
pyrene and enable a pH-controlled triggered release. A remarkably
narrow triggering pH interval was found where a change in pH from
6.4 to 6.9 allowed for release of the entire core content within seconds.
The degradation kinetics of the shell were measured by both spectrophotometric
detection of degradation products and mass changes by quartz crystal
microbalance with dissipation monitoring and were found to correlate
excellently with diffusion coefficients fitted to release measurements
at varying pH values. The microcapsules presented in this work allow
for an almost instantaneous triggered release even under mild conditions,
thanks to the designed core–shell morphology.