American Chemical Society
np1001913_si_001.pdf (1.92 MB)

Polyacetylenes from the Roots of Polyalthia debilis

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journal contribution
posted on 2010-08-27, 00:00 authored by Natcha Panthama, Somdej Kanokmedhakul, Kwanjai Kanokmedhakul
Six new linear polyacetylenic C25 and C27 acetogenins (16), named debilisones A−F, have been isolated from a methanol extract of roots of Polyalthia debilis. Structures of these compounds were determined by spectroscopic techniques. The absolute configuration at C-17 of 2 was assigned by the modified Mosher’s method. Compounds 2, 3, and 5 exhibited moderate antimycobacterial activity against Mycobacterium tuberculosis with MIC values of 25.0, 12.5, and 25.0 μg/mL, respectively.