Poly(Vinyl Alcohol) Enhances Acetylation of Ascorbic Acid in Superparamagnetic Graphene Oxide Nanoparticles Ultrasonically Complexed with Acetylsalicylic Acid

A single-step ultrasonic method (20 kHz) is demonstrated for the formation of acetylsalicylic acid-Fe₃O₄-graphene oxide nanocomposites (∼80 nm) in aqueous solution. The electronic molecular structure of these nanocomposites is stable in acidic or basic aqueous medium. Coating of these nanocomposites with poly­(vinyl alcohol) (PVA) occurs through increased binding with drug, magnetite, Fe­(II)–C–O and carbonaceous network of graphene oxide. PVA-coated-acetylsalicylic acid-Fe₃O₄-GO nanocomposites substantially improve acetylation of pristine ascorbic acid than free unmodified drug or uncoated acetylsalicylic acid-Fe₃O₄-GO nanoparticles because of enhanced electron density through the presence of magnetite and graphene oxide, and specific binding of PVA with drug and ascorbic acid.