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Plumisclerin A, a Diterpene with a New Skeleton from the Soft Coral Plumigorgia terminosclera
journal contribution
posted on 2010-03-05, 00:00 authored by María Jesús Martín, Rogelio Fernández, Andrés Francesch, Philippe Amade, Susana S. de Matos-Pita, Fernando Reyes, Carmen CuevasA novel compound, named plumisclerin A (1), was isolated from samples of the soft coral Plumigorgia terminosclera collected at Mayotte Island. The compound possesses the novel plumisclerane carbon skeleton, including a tricyclo[4,3,1,01,5]decane ring. Its structure and relative stereochemistry were elucidated by extensive spectroscopic analysis, including HREIMS, COSY, HSQC, HMBC, TOCSY, and NOESY experiments. In addition, the novel compound displayed in vitro cytotoxicity against selected cancer cell lines.