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Pitucamycin: Structural Merger of a Phenoxazinone with an Epoxyquinone Antibiotic

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journal contribution
posted on 24.09.2010, 00:00 by Patrícia Bezerra Gomes, Markus Nett, Hans-Martin Dahse, Christian Hertweck
Chemical profiling of a Streptomyces griseus strain isolated from an old building with moisture damage led to the discovery of two novel phenoxazinones, chandrananimycin D (1) and pitucamycin (2), along with the known grixazone B (3). Pitucamycin represents an unprecedented hybrid molecule composed of a phenoxazinone and an enaminomycin-like epoxyquinone moiety.